The lutropin/choriogonadotropin receptor, a 2002 perspective.
نویسندگان
چکیده
Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in the functions of the LHR during pregnancy have catastrophic consequences. As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor.
منابع مشابه
Molecular cloning of a novel luteinizing-hormone/human-chorionic-gonadotropin-receptor cDNA. Identification of a long 3' untranslated region and cDNA sequence of the major transcript in rat ovary.
The biological action of luteinizing hormone/human chorionic gonadotropin (lutropin/choriogonadotropin) in the ovary is mediated by interaction with its specific receptor. Lutropin/choriogonadotropin-receptor hnRNA is processed into multiple mRNAs. However, nucleotide sequences for many of the transcripts, including the major form (6.7 kb), have yet to be determined. In an attempt to identify a...
متن کاملStructural requirements for mutational lutropin/choriogonadotropin receptor activation.
Different activation mechanisms of glycoprotein hormone receptors, which are members of the G protein-coupled receptor superfamily, have been proposed. For example, the large ectodomain of glycoprotein hormone receptors may function as an inverse agonist keeping the transmembrane domain in an inactive conformation. To provide support for this hypothesis, we have generated different lutropin/cho...
متن کاملNa+ modulates the affinity of the lutropin/choriogonadotropin receptor.
The studies presented herein were designed to assess the effects of Na+ on the affinity of the lutropin/choriogonadotropin (LH/CG) receptor. We performed competition binding experiments in buffers containing NaCl or an isosmolar concentration of an appropriate Na+ substitute. The results presented show that Na+ decreases the affinity of LH, but not that of CG, in intact cells and membranes. In ...
متن کاملRat ovarian lutropin receptor is a transmembrane protein. Evidence for an Mr-20,000 cytoplasmic domain.
Membrane topography of the rat ovarian lutropin receptor was studied by two different approaches. Ovarian membrane preparation, labelled with 125I-labelled human choriogonadotropin in vivo, was subjected to extensive chymotryptic digestion. The soluble and membrane-bound radioactive complexes were cross-linked with glutaraldehyde, and analysed by SDS/polyacrylamide-gel electrophoresis and autor...
متن کاملInsights into the coexistence of two mutations in the same LHCGR gene locus causing severe Leydig cell hypoplasia.
BACKGROUND Leydig cell hypoplasia is a rare autosomal recessive condition that interferes with the normal development of male external genitalia in 46,XY individuals. It is mediated by mutations in the lutropin/choriogonadotropin receptor gene, resulting in the impairment of either the binding of hormone or signal transduction. OBJECTIVE/DESIGN We report a 32-year-old female patient with seve...
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ورودعنوان ژورنال:
- Endocrine reviews
دوره 23 2 شماره
صفحات -
تاریخ انتشار 2002